Jessica Flynn (NIH/NHLBI) et al.,
Amyloid fibrils have a characteristic architecture of well-ordered β-strands, leading to an alignment of amide bonds and strong coupled vibrational modes. Using Raman microspectroscopy, Flynn et al., found vibrational differences in α-synuclein fibrils and revealed molecular-level perturbations by Parkinson's disease–related mutations, offering a new method for characterizing amyloid structure.
Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy
J Biol Chem. 2018 Jan 19;293(3)
Illustrator: Erina He and Alan Hoofring