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Dr. Matthew F. Starost

​Title

Veterinary Pathologist, Staff Scientist

Education & Certifications

  • Diplomate: American College of Veterinary Pathologists
  • Ph.D. Oklahoma State University - Stillwater
  • D.V.M. University of Missouri - Columbia
  • B.S. SUNY @ Geneseo (NY)

Specialties or Areas of Expertise

  • Non-Human Primate Pathology
  • Middle and Inner Ear Disease
  • Mouse Models of Human Disease (Phenotyping)
  • Immunohistochemistry

Personal Interest

  • Boy Scouts of America
  • Hiking
  • Backpacking
  • Camping
  • High Adventure 

Publications 

  • Ferreyra GA, Elinoff JM, Demirkale CY, Starost MF, Buckley M, Munson PJ,Krakauer T, Danner RL. Late multiple organ surge in interferon-regulated target genes characterizes staphylococcal enterotoxin B lethality. PLoS One. 2014 Feb 13;9(2): e88756.
  • Lee SI, Conrad T, Jones SM, Lagziel A, Starost MF, Belyantseva IA, Friedman TB, Morell RJ. A null mutation of mouse Kcna10 causes significant vestibular and mild hearing dysfunction. Hear Res. 2013 Jun;300:1-9.
  • Gozalo AS, Zerfas PM, Starost MF, Lambert LE, Elkins WR. Pancreatic endocrine tumour with disseminated pulmonary thromboembolism in an owl monkey (Aotus nancymae). J Comp Pathol. 2013 Jul;149(1):132-6.
  • Dang Q, Whitted S, Goeken RM, Brenchley JM, Matsuda K, Brown CR, Lafont BA, Starost MF, Iyengar R, Plishka RJ, Buckler-White A, Hirsch VM. Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques. J Virol. 2012 Dec;86(24):13795-9.
  • Chen CY, Chi YH, Mutalif RA, Starost MF, Myers TG, Anderson SA, Stewart CL, Jeang KT. Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell. 2012 Apr 27;149(3):565-77.
  • Sung HJ, Ma W, Starost MF, Lago CU, Lim PK, Sack MN, Kang JG, Wang PY, Hwang PM. Ambient oxygen promotes tumorigenesis. PLoS One. 2011 May 12;6(5):e19785.
  • Watashi K, Yeung ML, Starost MF, Hosmane RS, Jeang KT. Identification of small molecules that suppress microRNA function and reverse tumorigenesis. J Biol Chem. 2010 Aug 6;285(32):24707-16.
  • Gozalo AS, Zerfas PM, Starost MF, Elkins WR, Clarke CL. Splenic angioleiomyoma in an owl monkey (Aotus nancymae). J Med Primatol. 2010 Dec;39(6):385-8.
  • Zerfas PM, Brinster LR, Starost MF, Burkholder TH, Raffeld M, Eckhaus MA. Amelanotic melanoma in a New Zealand White Rabbit (Oryctolagus cuniculus). Vet Pathol. 2010 Sep;47(5):977-81.
  • Tsang KM, Starost MF, Nesterova M, Boikos SA, Watkins T, Almeida MQ, Harran M, Li A, Collins MT, Cheadle C, Mertz EL, Leikin S, Kirschner LS, Robey P, Stratakis CA. Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8683-8.
  • Almeida MQ, Muchow M, Boikos S, Bauer AJ, Griffin KJ, Tsang KM, Cheadle C, Watkins T, Wen F, Starost MF, Bossis I, Nesterova M, Stratakis CA. Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/- or Rb1+/- backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling. Hum Mol Genet. 2010 Apr 15;19(8):1387-98.
  • Starost MF, Tsang K, Zerfas PM, Stratakis CA. A rhabdomyoma within a multilocular thymic cyst in a p53-null mouse. Vet Pathol. 2010 Jan;47(1):132-6.
  • Starost MF. Adenomyofibroma of the fimbria in a cynomolgus monkey (Macaca fascicularis). J Vet Diagn Invest. 2009 Nov;21(6):892-4.
  • Schultz JM, Khan SN, Ahmed ZM, Riazuddin S, Waryah AM, Chhatre D, Starost MF, Ploplis B, Buckley S, Velásquez D, Kabra M, Lee K, Hassan MJ, Ali G, Ansar M, Ghosh M, Wilcox ER, Ahmad W, Merlino G, Leal SM, Riazuddin S, Friedman TB, Morell RJ. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. Am J Hum Genet. 2009 Jul;85(1):25-39.
  • Yiu WH, Pan CJ, Mead PA, Starost MF, Mansfield BC, Chou JY. Normoglycemia alone is insufficient to prevent long-term complications of hepatocellular adenoma in glycogen storage disease type Ib mice. J Hepatol. 2009 Nov;51(5):909-17. .
  • Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y, Parlow AF, Gavrilova O, Szalayova I, Mezey E, Wess J. Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6398-403.
  • Yedavalli VS, Zhang N, Cai H, Zhang P, Starost MF, Hosmane RS, Jeang KT. Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication. J Med Chem. 2008 Aug 28;51(16):5043-51.
  • Starost MF, Burkholder TH. Acalculous and clostridial cholecystitis in a pig. J Vet Diagn Invest. 2008 Jul;20(4):527-30.
  • Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J. 2008 Feb 20;27(4):629-41.
  • Kim SY, Weinstein DA, Starost MF, Mansfield BC, Chou JY. Necrotic foci,elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia. J Hepatol. 2008 Mar;48(3):479-85.
  • Yiu WH, Pan CJ, Ruef RA, Peng WT, Starost MF, Mansfield BC, Chou JY. Angiotensin mediates renal fibrosis in the nephropathy of glycogen storage disease type Ia. Kidney Int. 2008 Mar;73(6):716-23.
  • Galeano B, Klootwijk R, Manoli I, Sun M, Ciccone C, Darvish D, Starost MF,Zerfas PM, Hoffmann VJ, Hoogstraten-Miller S, Krasnewich DM, Gahl WA, Huizing M. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J Clin Invest. 2007 Jun;117(6):1585-94.
  • Wassif CA, Brownson KE, Sterner AL, Forlino A, Zerfas PM, Wilson WK, Starost MF, Porter FD. HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency. Hum Mol Genet. 2007 May 15;16(10):1176-87.
  • Kono M, Belyantseva IA, Skoura A, Frolenkov GI, Starost MF, Dreier JL, Lidington D, Bolz SS, Friedman TB, Hla T, Proia RL. Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem. 2007 Apr 6;282(14):10690-6.
  • Starost MF. Solitary biliary hamartoma with cholelithiasis in a domestic rabbit (Oryctolagus cuniculus). Vet Pathol. 2007 Jan;44(1):92-5.
  • Shrimali RK, Weaver JA, Miller GF, Starost MF, Carlson BA, Novoselov SV, Kumaraswamy E, Gladyshev VN, Hatfield DL. Selenoprotein expression is essential in endothelial cell development and cardiac muscle function. Neuromuscul Disord. 2007 Feb;17(2):135-42.
  • Sabaawy HE, Azuma M, Embree LJ, Tsai HJ, Starost MF, Hickstein DD. TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15166-71.
  • Hoenerhoff MJ, Starost MF, Ward JM. Eosinophilic crystalline pneumonia as a major cause of death in 129S4/SvJae mice. Vet Pathol. 2006 Sep;43(5):682-8.
  • Wood CE, Usborne AL, Starost MF, Tarara RP, Hill LR, Wilkinson LM, Geisinger KR, Feiste EA, Cline JM. Hyperplastic and neoplastic lesions of the mammary gland in macaques. Vet Pathol. 2006 Jul;43(4):471-83.
  • Burkholder TH, Colenda L, Tuschong LM, Starost MF, Bauer TR Jr, Hickstein DD. Reproductive capability in dogs with canine leukocyte adhesion deficiency treated with nonmyeloablative conditioning prior to allogeneic hematopoietic stem cell transplantation. Blood. 2006 Sep 1;108(5):1767-9.
  • Karjala Z, Desch CE, Starost MF. First description of a new species of Demodex (Acari: Demodecidae) from rhesus monkey. J Med Entomol. 2005 Nov;42(6):948-52.
  • Gu YC, Bauer TR, Sokolic RA, Hai M, Tuschong LM, Burkholder T, Bacher J, Starost MF, Hickstein DD. Conversion of the severe to the moderate disease phenotype with donor leukocyte microchimerism in canine leukocyte adhesion deficiency. Bone Marrow Transplant. 2006 Mar;37(6):607-14.
  • Sokolic RA, Bauer TR, Gu YC, Hai M, Tuschong LM, Burkholder T, Colenda L, Bacher J, Starost MF, Hickstein DD. Nonmyeloablative conditioning with busulfan before matched littermate bone marrow transplantation results in reversal of the disease phenotype in canine leukocyte adhesion deficiency. Biol Blood Marrow Transplant. 2005 Oct;11(10):755-63.
  • Starost MF, Karjala Z, Brinster LR, Miller G, Eckhaus M, Bryant M, Hoffman V. Demodex spp. in the hair follicles of rhesus macaques (Macaca mulatta). J Med Primatol. 2005 Aug;34(4):215-8.
  • Kundu M, Compton S, Garrett-Beal L, Stacy T, Starost MF, Eckhaus M, Speck NA, Liu PP. Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma. Blood. 2005 Nov 15;106(10):3621-4.
  • Bauer TR Jr, Gu YC, Tuschong LM, Burkholder T, Bacher JD, Starost MF, Donahue RE, Sokolic RA, Hickstein DD. Nonmyeloablative hematopoietic stem cell transplantation corrects the disease phenotype in the canine model of leukocyte adhesion deficiency. Exp Hematol. 2005 Jun;33(6):706-12.
  • Spiridonov NA, Wong L, Zerfas PM, Starost MF, Pack SD, Paweletz CP, Johnson GR. Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Mol Cell Biol. 2005 May;25(10):4250-61.
  • Preston EH, Xu H, Dhanireddy KK, Pearl JP, Leopardi FV, Starost MF, Hale DA, Kirk AD. IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. Am J Transplant. 2005 May;5(5):1032-41.
  • Sugaya M, Watanabe T, Yang A, Starost MF, Kobayashi H, Atkins AM, Borris DL, Hanan EA, Schimel D, Bryant MA, Roberts N, Skobe M, Staskus KA, Kaldis P,Blauvelt A. Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter. Blood. 2005 Mar 15;105(6):2356-63.
  • Ohtsubo T, Rovira II, Starost MF, Liu C, Finkel T. Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2. Circ Res. 2004 Nov 26;95(11):1118-24.
  • Gu YC, Bauer TR Jr, Ackermann MR, Smith CW, Kehrli ME Jr, Starost MF, Hickstein DD. The genetic immunodeficiency disease, leukocyte adhesion deficiency, in humans, dogs, cattle, and mice. Comp Med. 2004 Aug;54(4):363-72.
  • Starost MF, Hill LR, Nehete PN, Sastry KJ. Extramedullary hematopoiesis in the mandibular lymph node of simian-human immunodeficiency virus-infected rhesus monkeys (Macaca mulatta): a report of three cases. Vet Pathol. 2004 Mar;41(2):186-90.
  • Creevy KE, Bauer TR Jr, Tuschong LM, Embree LJ, Colenda L, Cogan K, Starost MF, Haskins ME, Hickstein DD. Canine leukocyte adhesion deficiency colony for investigation of novel hematopoietic therapies. Vet Immunol Immunopathol. 2003 Jul 15;94(1-2):11-22.
  • Starost MF, Martino M. Adenoma of the gallbladder in a chimpanzee (Pan troglodytes). J Zoo Wildl Med. 2002 Jun;33(2):176-7.
  • Kleiner HE, Vulimiri SV, Starost MF, Reed MJ, DiGiovanni J. Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice. Carcinogenesis. 2002 Oct;23(10):1667-75.
  • Benavides F, Starost MF, Flores M, Gimenez-Conti IB, Guénet JL, Conti CJ.Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. Am J Pathol.2002 Aug;161(2):693-703.
  • Starost MF, Benavides F, Conti CJ. A variant of pulmonary alveolar microlithiasis in nackt mice. Vet Pathol. 2002 May;39(3):390-2.
  • Starost MF. Haemophilus somnus isolated from a urachal abscess in a calf. Vet Pathol. 2001 Sep;38(5):547-8.
  • Cook JL, Cook CR, Tomlinson JL, Millis DL, Starost M, Albrecht MA, Payne JT. Scapular fractures in dogs: epidemiology, classification, and concurrent injuries in 105 cases (1988-1994). J Am Anim Hosp Assoc. 1997 Nov-Dec;33(6):528-32.
  • Casteel SW, Cowart RP, Weis CP, Henningsen GM, Hoffman E, Brattin WJ, Guzman RE, Starost MF, Payne JT, Stockham SL, Becker SV, Drexler JW, Turk JR. Bioavailability of lead to juvenile swine dosed with soil from the Smuggler Mountain NPL Site of Aspen, Colorado. Fundam Appl Toxicol. 1997 Apr;36(2):177-87.