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Myrna Mandel, Ph.D.

​Title

  • Molecular Biologist
  • Chief, Laboratory of Molecular Biology and Microbiology
  • Office of the Director / Staff Scientist

Education & Certifications

  • Cornell University, Bachelor of Science in Microbiology
  • Cornell University, Master of Science in Microbiology
  • Cornell University, Ph.D. in Microbiology, minors in Biochemistry and Microbial Genetics

Specialties or Areas of Expertise

  • Molecular Genetics
  • Microbiology
  • Biochemistry
  • Neuroscience

Personal Interest

 Cooking, Literature, Music, Movies, Art

Publications 

  • Gewirtz, M. Elucidation of glycolytic and pentose phosphate enzyme patterns for characterization of the mycoplasmas. Cornell University dissertation, 1973.
  • Gewirtz, M. and Van Demark, P. Elucidation for modified glycolytic and pentose phosphate pathways in a non-fermentative mycoplasma. Bact. Proc. 45: 77, 1966.
  • Mickel, H., Hobar, J., and Gewirtz, M. Effect of inert gases and nitrogen on the peroxidation of unsaturated fatty acids. La Revista Italiana della Sostanze Grasse, 1977.
  • Lorenzo, A.V. and Gewirtz, M. Inhibition of 14C-tryptophan transport into the brain of lead-exposed neonatal rabbits. Brain Research, 132: 386-92, 1977.
    Lorenzo, A.v., Gewirtz, M., Maher, C., and Davidowski, L.J. Equilibration of lead between blood and milk of lactating rabbits. Life Science, 21: 1678-84, 1977.
  • Lorenzo, A.V., Gewirtz, M., and Averill, D. CNS lead toxicity in rabbit off-spring. Environmental Research, 17: 131-50, 1978.
  • Lorenzo, A.V. and Gewirtz, M. The effect of lead on tryptophan transport into the brain. Pharmacologist, 18:201, 1976.
  • Lorenzo, A.V. and Gewirtz, M. Neonatal lead exposure delays maturation of cerebrovascular permeability. Trans. Amer. Soc. Neurochemists, 8: 231, 1977.
  • Lorenzo, A.V. and Gewirtz, M. Effect of d-amphetamine on locomotor activity of lead-fed rabbit neonates. Pharmacologist, 19: 180, 1977.
  • Gewirtz, M. and Lorenzo, A.V. Regional lead distribution in the CNS and periphery of neonatal rabbits. Amer. Soc. Neurochem., 1978.
  • Lorenzo, A.V. and Gewirtz, M. Tryptophan, 5-HT and 5-HIAA levels in the plasma and brain of lead-fed neonates. Amer. Soc. Neurochem., 1978.
  • Lorenzo, A.V. and Gewirtz, M. Lead exposure retards development of thermoregulation in newborn rabbits. Amer. Soc. Neurochem., 1977.
  • Lorenzo, A.V. and Gewirtz, M. Effect of d-amphetamine on locomotor activity of lead-fed rabbit neonates. Pharmacologist, 19: 180, 1977.
  • Gewirtz, M. and Lorenzo, A.V. Regional lead distribution in the CNS and periphery of neonatal rabbits. Amer. Soc. Neurochem., 1978.
  • Lorenzo, A.V. and Gewirtz, M. Tryptophan, 5-HT and 5-HIAA levels in the plasma and brain of lead-fed neonates. Amer. Soc. Neurochem., 1978.
  • Lorenzo, A.V. and Gewirtz, M. Lead exposure retards development of thermoregulation in newborn rabbits. Amer. Soc. Neurochem., 1977.
  • Mandel, Myrna G. and Wilson, David B. The 6K bacteriophage lambda protein is a heat shock protein. Paper presented at the 1985 meeting on Molecular Genetics of Bacteria and Phages, Cold Spring Harbor Laboratory, Cold Spring, New York, August 22, 1985.
  • Mandel, M., Moriyama, J.Y., Hulmes, J.D., Pan, Y.-C.E., Nelson, N., and Nelson, H. cDNA sequence encoding the 16-kDa proteolipid of chromaffin granules implies gene duplication in the evolution of H+-ATPases. Proc. Natl. Acad. Sci. USA, 85: 5521, 1988.
  • Wang, S.-Y., Moriyama, Y., Mandel, M.G., Hulmes, J.D., Pan, Y.-C.E., Danho, W., Nelson, H., Nelson, N. Cloning of the cDNa encoding a 32-kDa protein. An accessory polypeptide of the H+-ATPase from chromaffin granules. J. Biol. Chem. 263: 17638, 1988.
  • Mandel, M., Greene, L., and Eisenberg, E. The cloning and sequencing of a bovine heat-shock gene that substitutes for yeast ssA genes (to be submitted).
    Mandel, Myrna, Preliminary results on DNA fingerprinting in genetic monitoring for rodent colonies, presentation at 1993 Annual Meeting of the US-Japan Animal Science Group, 11/23/93.
  • Mandel,M.G.,O'Neil, T., Lanier, L., Crowell, J. DNA fingerprinting of rodents in the NIH repository. Poster Session I at the NIH Research Festival, 9/19/94.
  • Mandel,M.G.,O'Neil, T., Lanier, L., Crowell, J. DNA fingerprinting of rodents in the NIH repository. Poster Session at the 45th American Association for Laboratory Animal Science, (AALAS)Pittsburgh, PA, 10/17/94. Abstract in Contemporary Topics, 33, Pa-27, 7/94.
  • Madden, D.L., Mandel, M.G., Eckhaus, M.A. Quality control of animals used in experimental model studies, presentation at meeting, Animal Models in Medical Research, India,12/94.
  • Mandel, M.G. Genetic Monitoring for the NIHAGR, presentation for the NIHAGR Advisory Group, 5/24/95
  • Mandel, M.G. Molecular Identification of Pathogens and Inbred Strains, Moderator and Presenter:DNA Fingerprinting of Rodents and other Mammals at the 23rd Annual NCAB /AALAS Conference,Ellicott City,MD, 9/18 & 9/19/96.
  • Mandel, M.G. The Utilization of DNA Fingerprinting, presentation
    at the Tribranch Symposium of AALAS, Lake Harmony,PA, 6/03/97.
  • Feldman,S.H., Cushion, M.T., Mandel, M.G., Geistfeld,J.G., Weisbroth, S.P., & Weisbroth, S.H., Detection of Pneumocystis carinii in Immunocompetent Sprague-Dawley Rats, using Semiquantitative Polymerase Chain Reaction Assay: Correlation of Detection by Polymerase Chain Reaction Testing with Age in an Enzootically Infected Colony, Abstract #PS13 in Contemporary Topics,36,page 45, 7/97.
  • Mandel, M.G. Augmenting Genetic Monitoring via DNA Fingerprinting -the Interface between Laboratory Animals and Molecular Biology, presentation at the 24th Annual Seminar of NCAB-AALAS, Turf Valley, MD, 9/10/97.
  • Mandel,M.G. Molecular Biology in Diagnostic Testing as a Component of the Emerging Use of Molecular Biology in Genetic Monitoring and Disease Detection, presentation at the 48th National Meeting of AALAS, Anaheim,CA ,11/17/97.
    Feldman,S.,Cushion,M.P.,Mandel,M.G.,Weisbroth,S.P., and Weisbroth, S.H. Detection of Pneumocystis carinii in Immunocompetent Sprague-Dawley Rats Using a Semiquantitative PCR,presentation at the 48th National Meeting of AALAS, Anaheim,CA, 11/17/97.
  • Madio,D.P., van Gelderen,P., DesPres,D., Olson,A.W.,de Zwart,J.A., Fawsett,T.,Holbrook,N.,Mandel,M., and Moonen, C. On the Feasibility of MRI-Guided Focused Ultrasound for Local Induction of Gene Expression. J. Magn. Reson. Imaging 8: 101-104, 1998.
  • Madio,D.P., van Gelderen,P., DesPres,D., Olsen,A.W., de Zwart,J.A.,
    Fawsett,T.,Holbrook,N.,Mandel,M.,Moonen,C. On the Feasibility of MRI-Guided Focused Ultrasound for Local Induction of Gene Expression, presentation at the International Society for Magnetic Resonance in Medicine, Vancouver, Canada, 4/97.
  • Wiener,S.M.,Hoyt,R.F., DeLeonardis,J.R., Jeffries,K., Nagashima,K.,
    Mandel,M., Owens,J., Eckhaus,M., Lutz,R.J., and Safer,B. Pressure-mediated Delivery to Specific Histological Compartments is Dependent upon Tight Junction Integrity. 2nd Annual Meeting of the American Society for Gene Therapy. Washington,D.C., 6/9/99 to 6/13/99.
  • Wiener,S.M.,Hoyt,R.F.,Clevenger,R.R.,DeLeonardis,J.R.,Jeffries,K.,Mandel,M.,Christini,D.V.,Lutz,R.J.,and Safer,B. Physiological Changes During Constant-pressure Retrograde Biliary Infusion in Mice,2nd Annual Meeting of the Society for Gene Therapy. Washington,D.C., 6/9/99 to 6/13/99.
  • Wiener,S.M.,Hoyt,R.F,Jr.,Jeffries,K.,DeLeonardis,J.R.,Clevenger,R.R.,Lipovsky,K.,Lowe,M.,Mandel,M.,Christini,D.J.,Lutz,R.J., and Safer,B. Chronic Choestasis reduces Biliary Pressure Response and Paracellular Leakage during Retrograde Biliary Infusion in Mice, 3rd Annual Meeting of the American Society of Gene Therapy. Denver,CO,5/31/2000 to 6/4/2000. Abstract #637 in Molecular Therapy ,1,page S232 (May,2000).
  • Mandel,M.G.Genetic Quality Assurance, presentation for Rat Auto-immune Priority Workshop, NIH, Bethesda,MD (1/19/2000 to 1/20/2000).
  • Madio,D.P.,vanGelderen,P.,DesPres,D.,Olson,A.W.,deZwart,J.A.,Faw-cett,T.W.,Holbrook,N.,Mandel, M., and Moonen,C.T.W.Induction of Gene Expression,in Fast Magnetic Resonance Imaging for Control of Localized Hyperthermia in Medicine , Chapter 11, 2000.
  • Wiener,S.M.,Hoyt,R.F.,Jr.,DeLeonardis,J.R.,Clevenger,R.R.,Jeffries,
    K.R.,Nagashima,K.,Mandel, M.,Owens,J.,Eckhaus,M.,Lutz,R.J., and
    Safer,B. Manometric Changes during Retrograde Biliary Infusion in Mice. Am. Jour.Physiol.Gastrointest.Liver Physiol., 279:G49 - G66, 2000.
  • Wiener,SM.,Hoyt,R.F.,Clevenger,R.R.,Lutz,R.,Mandel,M.,Safer,B., and Brewer,B. Pressure-Controlled Retrograde Biliary Infusion in Rabbits Permits Paracellular Passage and Subepithelial Tissue Compartment Delivery of Molecules Up to 2,000,000 Da., 4th Annual Meeting of the American Society of Gene Therapy.Pittsburgh,PA,5/30/2001 to 6/3/2001. Abstract #499 in Molecular Therapy,3 ,page S177(May, 2001).
  • Ward,J.M.,Wobus,C.E.,Thackray,L.B.,Erexson,C.R.,Faucette,L.J.,
    Belliot,G.,Copeland,M.K.,Mandel,M.,Barron,E.L.,Sosnovtsev,S.V.,and
    Green,K.Y. Naturally-Occurring Murine Norovirus Infection in Immunodeficient and Immunocompetent Mice., Poster at the 32nd Annual NCAB /AALAS Conference,Ellicott City,MD, 9/13 & 9/14/2006.
  • Ward,J.M.,Wobus,C.E.,Thackray,L.B.,Erexson,C.R.,Faucette,L.J.,
    Belliot,G.,Copeland,M.K.,Mandel,M.,Barron,E.L.,Sosnovtsev,S.V.,and
    Green,K.Y. Naturally-Occurring Murine Norovirus Infection in Immunodeficient and Immunocompetent Mice., 57th Annual Meeting of the American College of Veterinary Pathologists.Tucson,Arizona, 12/2/2006 to 12/6/2006. Abstract in Veterinary Pathology (Sept.,2006).
  • Perdue,K.A., Green, K.Y., Copeland, M., Barron, E., Mandel, M., Faucette, L.J., Williams, E.M., Sosnovtsev, S.V., Elkins, W.R., and Ward, J.M.. Naturally Occurring Murine Norovirus Infection in a Large Research Institution. J Am Assoc Lab Anim Sci 46:10-16, 7/ 2007.
  • Karjala, Z., Mandel, M., and Copeland, M. Detection of Spironucleus muris in unpreserved tissue and fecal samples using Polymerase Chain Reaction., Poster at 33rd Annual NCAB /AALAS Seminar, Turf Valley, Ellicott City,MD, 9/19 & 9/20/2007
    Kumwilaisak, K., Berra, L., Crimi, C., Pivi, S., Ufberg, J., Mandel, M., and Bigatello, L. Markers of Aspiration in Intubated Patients in a Surgical ICU., Poster Discussion Section at American Thoracic Society Meeting, Toronto, Canada, 3/19/08.