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Adoptive T cell therapy (ACT) using ex vivo–expanded autologous tumor-infiltrating lymphocytes (TILs) can mediate complete regression of certain human cancers. The impact of TIL phenotypes on clinical success of TIL-ACT is currently unclear. Using high-dimensional analysis of human ACT products, we identified a memory-progenitor CD39-negative stem-like phenotype (CD39−CD69−) associated with complete cancer regression and TIL persistence and a terminally differentiated CD39-positive state (CD39+CD69+) associated with poor TIL persistence.

Other authors and affiliations: Sri Krishna, Frank J. Lowery, Amy R. Copeland, Erol Bahadiroglu, Ratnadeep Mukherjee, James T. Anibal, Abraham Sachs, Serifat O. Adebola, Devikala Gurusamy1, View ORCID ProfileZhiya Yu1, Victoria Hill, Jared J. Gartner, Yong F. Li, Maria Parkhurst, Biman Paria1, Pia Kvistborg, Michael C. Kelly, Stephanie L. Goff, Grégoire Altan-Bonnet, Paul F. Robbins, Steven A. Rosenberg

Chloroquine (CQ) and hydroxychloroquine (HCQ) have been used as antiviral agents for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2) infection. We performed a systematic review to examine whether prior clinical studies that compared the effects of CQ and HCQ to a control for the treatment of non‐SARS‐CoV2 infection supported the use of these agents in the present SARS‐CoV2 outbreak.

This study characterizes rheumatological manifestations of GATA2 deficiency. Results: Rheumatological findings were identified in 28 patients, out of 157 cases reviewed (17.8%). Twenty-two of those patients (78.6%) reported symptom onset prior to or in conjunction with the molecular diagnosis of GATA2 deficiency.

For 50 years, the Fogarty International Center (FIC) has built research capacity particularly in low and middle-income countries responding to national and global public health priorities.

FIC provides a bridge between NIH and the greater global health community by facilitating exchanges among investigators, providing training opportunities and supporting promising research initiatives in developing countries.

Known originally for their use in nuclear air cleaning systems, high efficiency particulate air (HEPA) filters containing specialized media are now commonplace in the biomedical, aerospace, pharmaceutical, and clinical care settings.

As an engineering control, HEPA filters are the crux of the biological safety cabinet’s (BSC) performance and are essential for achieving filtration standards in clean rooms.

T cells undergo metabolic reprogramming with major changes in cellular energy metabolism during activation. In summary, the findings presented herein emphasize the role of COX particularly in T cells as a metabolic checkpoint for cell fate decisions following T cell activation, with heterogeneous effects in T cell subsets.

In addition, our studies highlight the utility of translational models that recapitulate human mitochondrial disease for understanding immunometabolism.

Industrial hygiene practitioners are often consulted to recommend personal protective equipment (PPE) as a control strategy to minimize worker exposure to biological, chemical, and physical hazards.

When selecting laboratory coats, the industrial hygienist is concerned with limitations of dexterity, durability, employee comfort, and compatibility with the hazard of concern. These and other criteria provide the framework for an organization’s PPE program.

In this paper we describe individuals with biallelic mutations in LAMA1, all of whom had the cerebellar dysplasia, myopia and retinal dystrophy, in addition to obsessive compulsive traits, tics and anxiety. Patient-derived fibroblasts have impaired adhesion, reduced migration, abnormal morphology and increased apoptosis due to impaired activation of Cdc42, a member of the Rho family of GTPases that is involved in cytoskeletal dynamics. LAMA1 knockdown in human neuronal cells also showed abnormal morphology and filopodia formation, supporting the importance of LAMA1 in neuronal migration, and marking these cells potentially useful tools for disease modelling and therapeutic target discovery.